May 1, 2017

Prof. Kate Carroll of Scripps Research Institute extended covalent drug discovery to cysteine-oxidized proteins by developing a library of nucleophilic drug candidates. For example, Prof. Carroll provided pyrolidinedione nucleophiles that react with protein tyrosine phosphatases.

See J.AmChem.Soc. 2017, DOI:10.1021/jacs.7b01791

http://pubs.acs.org/doi/10.1021/cen-09517-notw7

US 2016/0195532 “Targeted Covalent Probes and Inhibitors of Proteins Containing Redox-Sensitive Cysteines”